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The discontinuation rates were 10% for the 5-mg tirzepatide group, 12% for the 10-mg tirzepatide group, 18% for the 15-mg tirzepatide group, and 3% for the placebo group
The primary endpoint was hemoglobin A1c (HbA1c) levels after 6 months treatment [1]
Mean Insulin Secretion Rate Versus Glucose Concentration in Patients with Type 2 Diabetes during Graded Glucose Infusion before (Baseline) and after 12 Weeks of Treatment with Semaglutide or Placebo and in Untreated Healthy Subjects During induced hypoglycemia, semaglutide did not alter the counter regulatory responses of increased glucagon compared to placebo and did not impair the decrease of C-peptide in patients with type 2 diabetes
Cardiovascular Risk Profile: Even without significant obesity, patients with established heart disease, prior stroke, or multiple cardiac risk factors benefit from the cardiovascular protective effects beyond weight loss alone
A series of experiments elucidating the mechanisms of sirtuins [20:45]
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