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doi:10.1016/s00916749(97)800085 van den Berg NWE, Neefs J, Berger WR, et al

Another placebo-controlled study 35 reported clinical improvement alongside circadian biomarker assessment, noting that seven participants had more than a 10-point decrease in DSM-III-R depression score after ALC treatment

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These observations for TGFBI and TTR suggest that lower circulating levels of these islet-associated proteins could reflect changes in beta cell function accompanying type 1 diabetes