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In this cohort study, most patients with overweight or obesity discontinued GLP-1 RA therapy within 1 year, but those without type 2 diabetes had higher discontinuation rates and lower reinitiation rates, the researchers concluded
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Diabetes 54 , 16151625 (2005)
The reason is entirely about gastrointestinal tolerability nausea, diarrhea, and vomiting were clearly dose-dependent and concentrated in the weeks right after each step-up
In clinical studies, GLP-1 medications offer a protective element that supports endothelial function
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