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Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy

This is likely due to temporary hair loss triggered by significant bodily changes, such as rapid weight loss or nutritional deficiencies

To correct for this, we performed RNA-seq analysis of hypothalami obtained from animals treated with daily injections of either GLP-1MK-801 or a dose of semaglutide that was equipotent in terms of weight-lowering efficacy over 5 days of treatment, that is, mice had achieved a comparable weight loss and reduction in food intake as that of GLP-1MK-801-treated mice (Extended Data Fig

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This weight loss itself is highly beneficial for managing PCOS, as losing even 5-10% of body weight can improve insulin sensitivity, potentially regulate menstrual cycles, reduce androgen levels, and improve fertility in some women

Seven out of 20 studies reported an overall high risk of bias, due to bias from the randomization process, bias due to missing outcome data, bias in measurement of the outcome, and bias in selection of the reported result