Treatment regimen ranges from localized therapies for cutaneous lesions to systemic, often toxic approaches for DCL, ML, and VL ( Leishmania parasites to evade the host immune response and persist despite treatment has prompted a reevaluation of current therapeutic strategies ( Leishmania exploits some host metabolic pathways such as arginine, thiol, and polyamine syntheses to thrive in the hostile environment of the host macrophages
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2014 Jun 6;269:143-51 Authors: Karalija A, Novikova LN, Kingham PJ, Wiberg M, Novikov LN Abstract Traumatic spinal cord injury induces a long-standing inflammatory response in the spinal cord tissue, leading to a progressive apoptotic death of spinal cord neurons and glial cells
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