The ketone bodies [acetoacetate (AcAc) and -hydroxybutyrate (HB)], produced in the liver, can be transported with blood to other organs, including the brain, where they can be converted back to acetyl-CoA and used in the TCA cycle to produce ATP (14) (Figure 1)
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Importantly, they work best when combined with dietary changes and physical activity
Poor availability of treatment guidelines, lack of proper training and education, lack of awareness among patients and healthcare workers, and poor quality of healthcare services have restrained the adoption of insulin pens in the region
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PMID: 40368220 Exp Neurol Lactiplantibacillus plantarum SG5 inhibits neuroinflammation in MPTP-induced PD mice through GLP-1/PGC-1 pathway