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This seemingly small change has a massive impact: Increased Potency: It increases its potency by up to 10x in certain tissues

[00034] "Odor" as used herein refers to any pungent smell or stench

Ethics declarations Conflict of interest The authors declared no competing interests

GPX4 is a crucial selenoprotein that converts toxic lipid hydroperoxides (L-OOH) on the cytoplasmic membrane to non-toxic lipid alcohol (L-OH) by utilizing GSH, thus preventing the accumulation of lipid peroxidation to protect cells from ferroptosis (191)

Glenn Center for the Biological Mechanisms of Aging

Lets say that your target protein is smaller than GST, such that most of the size of the GST-fusion protein will be contributed from GST and not your target protein