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This timeline matters because it explains why BPI Labs and other compounders have pursued alternative formulations like the tirzepatide plus B6 combination, patent challenges, and other legal strategies to maintain their ability to produce tirzepatide products

Anyone who has severe gastroparesis or advanced gastrointestinal constipation problems not just occasional constipation shouldnt take a GLP-1

One 2023 study in Circulation even found that clearing senescent cells, including with FOXO4-DRI, worsened pulmonary hypertension in rodents

doi: 10.3389/fbioe.2020.00942 211 MathesiusU

Most of these are mild to moderate and improve over time

Understanding how these medications work and what to realistically expect can help you make informed decisions about your treatment