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Key Takeaways: Semaglutide Weight Loss Results Average total weight loss: 14.9% of body weight over 68 weeks (about 16 months) When results start: Most people notice initial weight loss in weeks 4-8 Peak effectiveness: Maximum weight loss typically occurs around month 16-17 Success rates: 86.4% of participants lost at least 5% of body weight, 69.1% lost 10% or more Dose progression: Youll start at 0.25 mg weekly and gradually increase to 2.4 mg over 16-20 weeks Individual variation: Your results depend on starting weight, adherence, diet, exercise, and metabolic factors How Semaglutide Works for Weight Loss Semaglutide belongs to a class of medications called GLP-1 receptor agonists