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Segmented visceral adipose tissue (VAT) is colored yellow, subcutaneous adipose tissue (SAT) is colored blue, skeletal muscle is colored red, liver is colored red, and spleen (not evaluated in present investigation) is colored orange

For many patients, the active ingredient is therefore not the only important difference, but also how the treatment fits into everyday life

The identification of these alternative immune checkpoints highlights the need for multi-targeted immunotherapeutic approaches that nanomedicine platforms are uniquely positioned to deliver ( Figure 1 )

Lang F, Busch GL, Ritter M, Volkl H, Waldegger S, Gulbins E, Haussinger D: Functional significance of cell volume regulatory mechanisms

Bilirubin and ischemic stroke: rendering the current paradigm to better understand the protective effects of bilirubin

For secondary endpoints, Cox proportional hazards and ANCOVA models were used for time-to-event and continuous outcomes, respectively