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Common adverse effects include gastrointestinal symptoms, which affect the majority of patients to varying degrees: Nausea (20-44% of patients) usually most pronounced during dose escalation Diarrhea (20-30%) Constipation (15-24%) Vomiting (9-24%) Abdominal pain (6-10%) These symptoms typically diminish over time as physiological adaptation occurs

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Vitamin A is part of the natural tear film and as such is very well tolerated as a lubricant

Dosage The dosage of semaglutide GLP-1 can impact how quickly it takes effect