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Chronic glutathione depletion confers protection against alcohol-induced steatosis: implication for redox activation of AMP-activated protein kinase pathway

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doi: 10.1210/jc.2010-2679 47 HjelholtAJLeeKYArlien-SborgMCPedersenSBKopchickJJPuriVet al

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A molcula encontrada naturalmente no plasma humano e vem sendo estudada h dcadas por possveis efeitos sobre regenerao tecidual, modulao inflamatria, cicatrizao e envelhecimento da pele

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Enzyme stability The cyclic disulfide bond structure makes it less likely to be degraded by proteases in adipose tissue, prolonging the action time

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These modifications in metabolism pathways resulted in a substantial increase in the levels of 48 metabolites such as Xanthine, ascorbate, Cys-Gly, kynurenine, phenylalanine, 5-hydroxykynurenine, and others as outlined in Supplementary Figures 5A, B

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