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IV delivery also avoids the gastrointestinal upset and diarrhea that commonly limit highdose oral vitamin C

The antagonistic effect, in which two hormones have opposing effects

But the logic can falter when extended too widely, said Grossman

In addition, GSSG retained in mitochondria during oxidative stress can lead to the S-gluthionylation of target proteins with mitochondrial dysfunction (20, 21)

Secondary analyses of RCTs typically demonstrate association rather than causation, unless the exposure of interest was randomized or robust causal inference methods are used and confounding is adequately controlled

However, the handful of studies available is promising