At present, clear clinical recommendations regarding the safety of GLP-1RAs for people with pre-existing depression or suicidal behavior cannot be made
The manuscript is under review but has not yet been published in a peer-reviewed journal
Tiredness may result from multiple factors including direct medication effects, inadequate caloric or nutritional intake due to reduced appetite, dehydration from gastrointestinal side effects, metabolic adaptation to weight loss, and blood sugar fluctuations in patients taking diabetes medications
Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells
It is worth noting that for currently licensed GLP-1 receptor agonists in the UK, the thyroid tumour signal is classified as a precautionary consideration based on rodent data, rather than a formal contraindication as reflected in UK Summaries of Product Characteristics (SmPCs)
The official prescribing information for Wegovy, for example, lists dysgeusia (a distortion of the sense of taste) as a reported side effect
