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Sleep restriction increases ghrelin (hunger) and decreases leptin (satiety), while elevated cortisol from stress promotes abdominal fat storage and increases cravings

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GLP1 receptor agonists (GLP1RAs) are established treatments for type 2 diabetes mellitus (T2DM) and obesity, with data that support positive effects on hard clinical end points such as cardiovascular events and renal outcomes

Certain genetic variants, carried by around 10 percent of the population, could be making type 2 diabetes GLP-1 treatments (such as Ozempic and Wegovy) less effective, according to new research