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Orforglipron (branded as Foundayo) is the first small molecule GLP-1 receptor agonist, distinguishing it from peptide-based options like semaglutide (Wegovy, Ozempic) and tirzepatide (Mounjaro, Zepbound)

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However, maximal benefit often emerges after 3-6 months as cumulative weight loss and sustained GLP-1 receptor activation take full effect