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If considering medication primarily for weight management, follow NICE NG246 guidance on overweight and obesity management

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Ischemia reperfusion protocol Following each four-week period of either GPLC or placebo intake, subjects underwent a protocol involving five minutes of upper arm cuff occlusion in conjunction with submaximal isometric handgrip dynamometry to induce ischemia

A personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) are contraindications

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