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While the primary patents on the albuterol molecule expired decades ago (in 1989), Teva maintained exclusivity through a fortress of secondary patents covering the hydrofluoroalkane (HFA) propellant formulation and the intricate mechanics of the inhaler device itself
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doi: 10.1210/jc.2005-1536 81 CorpasEHarmanSMPieyroMARobersonRBlackmanMR
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Off-label use means it hasnt been formally tested or approved for that specific use
