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A progressive decrease in body weight was also observed for up to 3 years in exenatide-treated patients [46,48]
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P.KalgutkarA
This dual mechanism is the pharmacological reason tirzepatide produces greater average weight loss than GLP-1 single-agonists in clinical trial data
The STEP 3 trial combining semaglutide with intensive behavioral therapy achieved 16.0% weight loss
Clinical data suggest this produces greater average weight loss compared to semaglutide alone
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