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Xgeva (2010) is indicated for the treatment of a significantly smaller patient population , i.e., for the prevention of SRE in solid tumor and multiple myeloma patients, giant cell tumor of bone, and hypercalcemia in patients refractory to bisphosphonate therapies

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Subgroup analysis for treatment durations 6 months indicated a higher WL in the GLP-1RAs group (SMD = 0.79, 95% CI 0.25 to 1.34)

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Individual results vary based on starting weight, dose, adherence, diet, and physical activity

The primary outcome of this pilot study was the induction of an anticancer proteome response at the end of 4th week during 4-week intermittent fasting and 1 week after 4-week intermittent fasting