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Short-acting GLP-1RAs exhibit a considerable fluctuation in circulating levels during the daytime that, in turn, produce an intermittent activation of GLP-1R, resulting in different pharmacodynamic effects compared to long-acting GLP-1RA (66)

If additional glycaemic control is needed after at least 30 days on 7 mg, the dose may be increased to 14 mg daily

J Pediatr Endocrinol Metab 2014;27((1-2)):23-29

Implications and future perspectives of AGEs in PCOS pathophysiology

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Article updated 12/17/2025 to reflect recent FDA communications, regulatory clarifications and clinical context related to GLP-1 medications