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The guidance of a health care professional and patient-specific considerations, i.e
Z.WarringtonJ.et al
Brand-name tirzepatide escalation (Mounjaro/Zepbound schedule) Notice the optional tiers at 7.5 mg and 12.5 mg
The clinical principle is to titrate antihypertensives downward as weight loss progresses, not to discontinue abruptly
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In the future, with the in-depth exploration of the mechanism of GLP-1R action and the development of multi-target agonists (e.g., GLP-1R/GIPR dual agonists), GLP-1R-related therapeutics are expected to make breakthroughs in a wider range of disease areas (e.g., nonalcoholic steatohepatitis, AD, etc.), providing a more precise and highly effective strategy for the treatment of metabolic diseases and related complications
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