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Therefore the overall impact on fertility that ROS has is not a matter of if it is there or not (as mentioned earlier, some oxidative stress is required for various reproductive physiological functions), but when levels of ROS are too high (or antioxidant levels are too low) it becomes pathological to sperm and the ability to get pregnant

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Those target genes include heme oxygenase 1 (HMOX-1), the main regulator of iron and heme metabolism (Suzen et al., 2022), NAD(P)H quinone dehydrogenase 1 (NQO-1), a reducer of ROS (quinones) (Ross and Siegel, 2021), and peroxiredoxin (PRX), which reduces peroxides (Chowdhury et al., 2009), among many others

Journal of Agricultural and Food Chemistry, 62 , 9499-9506

[1] Testing Grounds: The Trials and Outcomes of AOD-9604 AOD-9604's lipolytic potential has made it a compelling molecule for scientists and medical professionals looking to harness its potential for therapeutic purposes

*Correspondence: Peng Xu, [email protected] ORCID: Lin Liu, Jiachen Wang, Weikun Hou, This article was submitted to Molecular Diagnostics and Therapeutics, a section of the journal Frontiers in Molecular Biosciences Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers