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By acknowledging the active role of glial cells, securing robust biomarkers, and designing multimodal, personalized strategies, the field can move closer to genuine disease modification

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The role of DHAR proteins in ascorbate regeneration has been demonstrated in tobacco, since DHAR-downregulating tobacco lines show reduced total ascorbate levels, lower dry weight, and diminished photosynthetic efficiency (Chen and Gallie, 2006

J Hum Nutr Diet 35(6):11511163

Supporting metabolism, protecting lean mass, and addressing deficiencies early helps prevent the fatigue and plateaus that sometimes occur later in treatment