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suggested that TB-500 may reduce TLR-mediated inflammatory signaling within oligodendrocyte progenitor cell cultures by elevating miR-146a, a regulatory RNA molecule that may suppress downstream IRAK1 and TRAF6 activity
For patients with eGFR between 30-45 mL/min/1.73 m, a careful reassessment of benefit-risk is recommended with consideration of dose reduction
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