Unfortunately, glutathione levels decline with age, most specifically due to poor nutrition, stress, and to toxins from the environment
Digestive acids and enzymes can break down peptides before theyre absorbed
In general mB12/LDFA has a significant influence on redox regulation with medium effect sizes, particularly in the role of positively affecting glutathione metabolism and its precursors, whereas BH4 primarily has a positive effect on markers of oxidative damage as well as methylation metabolism with large effect sizes
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doi:10.1016/j.ctim.2019.102234 McFarlin BK, Henning AL, Bowman EM, Gary MA, Carbajal KM
For those who dont consume animal foods, such as vegetarians and vegans, there are plant-based sources of vitamin B12 available, including nutritional yeast, fortified foods, cereals, mushrooms, and certain types of algae