Because they work by making existing insulin more effective rather than increasing insulin levels directly, hypoglycemia is less of a concern than with sulfonylureas
We can also order many types of brain imaging studies to specifically quantify neuron damage and many diagnostic lab tests to help establish a proper detailed diagnosis in complex cases, and do trans-cranial doppler ultrasound imaging of brain and cerebrovascular flow as well as ultrasonic blood-brain barrier opening directly in the clinic
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Tirzepatide is a medication that improves insulin sensitivity, which can be evaluated indirectly through fasting biomarkers such as glucose and insulin and the homeostasis model assessment of insulin resistance (HOMA2-IR)
