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10.1161/JAHA.120.020301 6 BanK.Noyan-AshrafM
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This combination is aimed at patients who are insulin-dependent and need additional glucose control
Its structure, anchored in pharmacologic rationale, real-world feasibility, and patient safety, enables near-term implementation even as multicenter studies further define optimal hold durations, ultrasound cut-offs, and fertility outcomes
However, their clinical translation is often impeded by inherent challenges such as poor bioavailability, limited aqueous solubility, and rapid systemic clearance, which collectively hinder their effective delivery to targeted ocular tissues [347]
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