ebm medical tirzepatide The standard 2.5 mg starting dose of may be too high for some people. Some clinicians use lower customized doses in sensitive patients to reduce nausea, fatigue and excessive appetite suppression Tirzepatide vs semaglutide for weight

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36 Current evidence suggests a possible link to depressive or suicidal ideation specific to semaglutide 37, and a clearly higher incidence of gastrointestinal adverse events compared with liraglutide.38 Both remain FDA-approved and well-studied

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Clinical trials (SUSTAIN-6) have shown cardiovascular benefits with semaglutide, though this is not a specific licensed indication in the UK

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Its primary approved indication in the United States is the reduction of excess abdominal fat in HIV-positive adults with lipodystrophy, a condition characterised by abnormal fat redistribution often associated with antiretroviral therapy