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SEM = semaglutide

Competing Interest Statement All authors are employees of Truveta, Inc

Nausea and diarrhea were the most common side effects which were transient and improved with time, with less than 5% of the patients in the treatment group discontinuing treatment from gastrointestinal side effects

244 Therefore, a complex regulatory mechanism may underlie the modulation of TMAO metabolism by statins, necessitating further research to clarify the precise pathways involved and their clinical implications (Table 8)

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